Ontology highlight
ABSTRACT:
SUBMITTER: Catanzaro JR
PROVIDER: S-EPMC6753154 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Catanzaro Jason R JR Strauss Juliet D JD Bielecka Agata A Porto Anthony F AF Lobo Francis M FM Urban Andrea A Schofield Whitman B WB Palm Noah W NW
Scientific reports 20190919 1
Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that mucosal secretion of IgM can compensate for a lack of secretory IgA. We used 16S rRNA gene sequencing and bacterial cell sorting to evaluate gut microbiota composition an ...[more]