Ontology highlight
ABSTRACT:
SUBMITTER: Xie S
PROVIDER: S-EPMC6754110 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Xie Sheng S Zhou Juan J Chen Xuan X Kong Na N Fan Yanmiao Y Zhang Yang Y Hammer Gerry G Castner David G DG Ramström Olof O Yan Mingdi M
Materials chemistry frontiers 20181204 2
A tri-component reaction, involving an electrophilically-activated perfluoroaryl azide, an enolizable aldehyde and an amine, reacts readily at room temperature without any catalysts in solvents including aqueous conditions to yield a stable amidine conjugate. The versatility of this reaction is demonstrated in the conjugation of an amino acid without prior protection of the carboxyl group, and in the synthesize antibiotic-nanoparticle conjugates. ...[more]