Ontology highlight
ABSTRACT:
SUBMITTER: Stanley SY
PROVIDER: S-EPMC6754177 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Cell 20190829 6
Phages express anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems that would otherwise destroy their genomes. Most acr genes are located adjacent to anti-CRISPR-associated (aca) genes, which encode proteins with a helix-turn-helix DNA-binding motif. The conservation of aca genes has served as a signpost for the identification of acr genes, but the function of the proteins encoded by these genes has not been investigated. Here we reveal that an acr-associated promoter drives high levels of ...[more]