Ontology highlight
ABSTRACT:
SUBMITTER: Meng JL
PROVIDER: S-EPMC6754208 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Meng Julia L JL Marshall Zarion D ZD Lobb-Rabe Meike M Heckscher Ellie S ES
eLife 20190910
How circuits assemble starting from stem cells is a fundamental question in developmental neurobiology. We test the hypothesis that, in neuronal stem cells, temporal transcription factors predictably control neuronal terminal features and circuit assembly. Using the Drosophila motor system, we manipulate expression of the classic temporal transcription factor Hunchback (Hb) specifically in the NB7-1 stem cell, which produces U motor neurons (MNs), and then we monitor dendrite morphology and neur ...[more]