Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6754299 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Haoxin H Ericsson Maria M Rabasha Bokang B Budnik Bogdan B Chan Sze Ham SH Freinkman Elizaveta E Lewis Caroline A CA Doench John G JG Wagner Bridget K BK Garraway Levi A LA Schreiber Stuart L SL
Cell chemical biology 20190613 9
The proteinaceous extracellular matrix (ECM) is vital for the survival, proliferation, migration, and differentiation of many types of cancer. However, little is known regarding metabolic pathways required for ECM secretion. By using an unbiased computational approach, we searched for enzymes whose suppression may lead to disruptions in protein secretion. Here, we show that 6-phosphogluconate dehydrogenase (PGD), a cytosolic enzyme involved in carbohydrate metabolism, is required for ER structur ...[more]