The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease.

ABSTRACT: Flavored e-cigarettes are preferred by the majority of users yet their potential toxicity is unknown. Therefore our aim was to determine the effect of selected flavored e-cigarettes, with or without nicotine, on allergic airways disease in mice. Balb/c mice were challenged with PBS or house dust mite (HDM) (Days 0, 7, 14-18) and exposed to room air or e-cigarette aerosol for 30?min twice daily, 6 days/week from Days 0-18 (n?=?8-12/group). Mice were exposed to Room Air, vehicle control (50%VG/%50PG), Black Licorice, Kola, Banana Pudding or Cinnacide without or with 12?mg/mL nicotine. Mice were assessed at 72?hours after the final HDM challenge. Compared to mice challenged with HDM and exposed to Room Air, nicotine-free Cinnacide reduced airway inflammation (p?=?0.045) and increased peripheral airway hyperresponsiveness (p?=?0.02), nicotine-free Banana Pudding increased soluble lung collagen (p?=?0.049), with a trend towards increased airway inflammation with nicotine-free Black Licorice exposure (p?=?0.089). In contrast, all e-cigarettes containing nicotine suppressed airway inflammation (p?

SUBMITTER: Chapman DG 

PROVIDER: S-EPMC6754426 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature