Ontology highlight
ABSTRACT:
SUBMITTER: Hu Z
PROVIDER: S-EPMC6754605 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hu Zehan Z Bang Ye-Ji YJ Ruhn Kelly A KA Hooper Lora V LV
Proceedings of the National Academy of Sciences of the United States of America 20190904 38
Serum amyloid A (SAA) proteins are strongly induced in the liver by systemic infection and in the intestine by bacterial colonization. In infected mice, SAA proteins circulate in association with the vitamin A derivative retinol, suggesting that SAAs transport retinol during infection. Here we illuminate a structural basis for the retinol-SAA interaction. In the bloodstream of infected mice, most SAA is complexed with high-density lipoprotein (HDL). However, we found that the majority of the cir ...[more]