Ontology highlight
ABSTRACT:
SUBMITTER: Kong R
PROVIDER: S-EPMC6755680 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cell 20190701 3
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab lineages targeting the HIV-1-fusion peptide (FP) in vaccinated macaques over time. Genetic and structural analyses revealed two of these lineages to belong to a reproducible class capable of neutralizing up to 59% of 208 diverse vir ...[more]