Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2584972 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Yuxing Y Migueles Stephen A SA Welcher Brent B Svehla Krisha K Phogat Adhuna A Louder Mark K MK Wu Xueling X Shaw George M GM Connors Mark M Wyatt Richard T RT Mascola John R JR
Nature medicine 20070826 9
We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine im ...[more]
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