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Chromatin regulatory mechanisms and therapeutic opportunities in cancer.

ABSTRACT: Research over the past several decades has unmasked a major contribution of disrupted chromatin regulatory processes to human disease, particularly cancer. Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified unexpected synthetic lethal opportunities and enabled increasingly comprehensive structural and functional dissection. Here, we review recent progress in our understanding of oncogenic mechanisms at each level of chromatin organization and regulation, and discuss new strategies towards therapeutic intervention.

SUBMITTER: Valencia AM

PROVIDER: S-EPMC6755910 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Chromatin regulatory mechanisms and therapeutic opportunities in cancer.

Valencia Alfredo M AM Kadoch Cigall C

Nature cell biology 20190102 2

Research over the past several decades has unmasked a major contribution of disrupted chromatin regulatory processes to human disease, particularly cancer. Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified unexpected synthetic lethal opportunities and enabled increasingly comprehensive structural and functional dissection. Here, we review recent progress in our understanding of oncogenic mechanisms at each level o ...[more]

PMID: 30602726

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