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Combination regimens of radiation therapy and therapeutic cancer vaccines: mechanisms and opportunities.

ABSTRACT: Radiation therapy (RT) is widely used with curative or palliative intent in the clinical management of multiple cancers. Although mainly aimed at direct tumor cell killing, mounting evidence suggests that radiation can alter the tumor to become an immunostimulatory milieu. Data suggest that the immunogenic effects of radiation can be exploited to promote synergistic antitumor effects in combination with immunotherapeutic agents. We review concepts associated with the immunogenic consequences of RT and highlight how preclinical findings are translating into clinical benefit for patients receiving combination regimens of RT and therapeutic cancer vaccines.

SUBMITTER: Garnett-Benson C

PROVIDER: S-EPMC4258617 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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Combination regimens of radiation therapy and therapeutic cancer vaccines: mechanisms and opportunities.

Garnett-Benson Charlie C Hodge James W JW Gameiro Sofia R SR

Seminars in radiation oncology 20150101 1

Radiation therapy (RT) is widely used with curative or palliative intent in the clinical management of multiple cancers. Although mainly aimed at direct tumor cell killing, mounting evidence suggests that radiation can alter the tumor to become an immunostimulatory milieu. Data suggest that the immunogenic effects of radiation can be exploited to promote synergistic antitumor effects in combination with immunotherapeutic agents. We review concepts associated with the immunogenic consequences of ...[more]

PMID: 25481266

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