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Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.


ABSTRACT: We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations. Most of these problems cannot be solved by individual centers working in isolation but warrant a truly collaborative effort that brings together all the major psychiatric genetic research centers in the Russian Federation in a national consortium. For this reason, we have established the Russian National Consortium for Psychiatric Genetics (RNCPG) with the aim to strengthen the power and rigor of psychiatric genetics research in the Russian Federation and enhance the international compatibility of this research.The consortium is set up as an open organization that will facilitate collaborations on complex biomedical research projects in human mental health in the Russian Federation and abroad. These projects will include genotyping, sequencing, transcriptome and epigenome analysis, metabolomics, and a wide array of other state-of-the-art analyses. Here, we discuss the challenges we face and the approaches we will take to unlock the huge potential that the Russian Federation holds for the worldwide psychiatric genetics community.

SUBMITTER: Fedorenko OY 

PROVIDER: S-EPMC6756082 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.

Fedorenko Olga Yu OY   Golimbet Vera E VE   Ivanova Svetlana А SА   Levchenko Аnastasia А   Gainetdinov Raul R RR   Semke Arkady V AV   Simutkin German G GG   Gareeva Аnna E АE   Glotov Аndrey S АS   Gryaznova Anna A   Iourov Ivan Y IY   Krupitsky Evgeny M EM   Lebedev Igor N IN   Mazo Galina E GE   Kaleda Vasily G VG   Abramova Lilia I LI   Oleichik Igor V IV   Nasykhova Yulia A YA   Nasyrova Regina F RF   Nikolishin Anton E AE   Kasyanov Evgeny D ED   Rukavishnikov Grigory V GV   Timerbulatov Ilgiz F IF   Brodyansky Vadim M VM   Vorsanova Svetlana G SG   Yurov Yury B YB   Zhilyaeva Tatyana V TV   Sergeeva Anzhelika V AV   Blokhina Elena A EA   Zvartau Edwin E EE   Blagonravova Anna S AS   Aftanas Lyubomir I LI   Bokhan Nikolay А NА   Kekelidze Zurab I ZI   Klimenko Tatyana V TV   Anokhina Irina P IP   Khusnutdinova Elza K EK   Klyushnik Tatyana P TP   Neznanov Nikolay G NG   Stepanov Vadim A VA   Schulze Thomas G TG   Kibitov Аleksandr О АО  

Molecular psychiatry 20190121 8


We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federa  ...[more]

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