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Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl Sulfides and Its Application in Fluorescent Probe Development.


ABSTRACT: A unique reaction between H2S and a selenenyl sulfide containing benzoate ester template was discovered. This reaction could be specifically triggered by H2S and lead to ester bond cleavage. The reaction was not affected by the presence of thiols such as glutathione and cysteine. With this reaction, a series of fluorescent probes were synthesized and evaluated. The probes exhibited high sensitivity/selectivity for H2S in both buffers and cells.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6756184 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl Sulfides and Its Application in Fluorescent Probe Development.

Wang Yingying Y   Yang Chun-Tao CT   Xu Shi S   Chen Wei W   Xian Ming M  

Organic letters 20190906 18


A unique reaction between H<sub>2</sub>S and a selenenyl sulfide containing benzoate ester template was discovered. This reaction could be specifically triggered by H<sub>2</sub>S and lead to ester bond cleavage. The reaction was not affected by the presence of thiols such as glutathione and cysteine. With this reaction, a series of fluorescent probes were synthesized and evaluated. The probes exhibited high sensitivity/selectivity for H<sub>2</sub>S in both buffers and cells. ...[more]

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