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Reaction based fluorescent probes for hydrogen sulfide.

ABSTRACT: A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.

SUBMITTER: Liu C

PROVIDER: S-EPMC3336739 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Reaction based fluorescent probes for hydrogen sulfide.

Liu Chunrong C Peng Bo B Li Sheng S Park Chung-Min CM Whorton A Richard AR Xian Ming M

Organic letters 20120409 8

A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide. ...[more]

PMID: 22486842

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