Ontology highlight
ABSTRACT:
SUBMITTER: Huang F
PROVIDER: S-EPMC6758558 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20181012 2
<h4>Introduction</h4>Altered cell cycle reentry has been observed in Alzheimer's disease (AD). Denticleless (DTL) was predicted as the top driver of a cell cycle subnetwork associated with AD.<h4>Methods</h4>We systematically investigated DTL expression in AD and studied the molecular, cellular, and behavioral endophenotypes triggered by DTL overexpression.<h4>Results</h4>We experimentally validated that CDT2, the protein encoded by DTL, activated cyclin-dependent kinases through downregulating ...[more]