Ontology highlight
ABSTRACT:
SUBMITTER: Campa VM
PROVIDER: S-EPMC2557048 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Campa Víctor M VM Gutiérrez-Lanza Raquel R Cerignoli Fabio F Díaz-Trelles Ramón R Nelson Brandon B Tsuji Toshiya T Barcova Maria M Jiang Wei W Mercola Mark M
The Journal of cell biology 20081001 1
The inability of heart muscle to regenerate by replication of existing cardiomyocytes has engendered considerable interest in identifying developmental or other stimuli capable of sustaining the proliferative capacity of immature cardiomyocytes or stimulating division of postmitotic cardiomyocytes. Here, we demonstrate that reactivation of Notch signaling causes embryonic stem cell-derived and neonatal ventricular cardiomyocytes to enter the cell cycle. The proliferative response of neonatal ven ...[more]