Ontology highlight
ABSTRACT:
SUBMITTER: Olsen RW
PROVIDER: S-EPMC6759304 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Olsen Rebecca W RW Ecklu-Mensah Gertrude G Bengtsson Anja A Ofori Michael F MF Kusi Kwadwo A KA Koram Kwadwo A KA Hviid Lars L Adams Yvonne Y Jensen Anja T R ATR
Infection and immunity 20190919 10
<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins bindin ...[more]