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Acquisition of IgG to ICAM-1-Binding DBL? Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C.


ABSTRACT: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBL? domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBL? domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBL? domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBL? domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBL? domains binding ICAM-1 differs between PfEMP1 groups.

SUBMITTER: Olsen RW 

PROVIDER: S-EPMC6759304 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C.

Olsen Rebecca W RW   Ecklu-Mensah Gertrude G   Bengtsson Anja A   Ofori Michael F MF   Kusi Kwadwo A KA   Koram Kwadwo A KA   Hviid Lars L   Adams Yvonne Y   Jensen Anja T R ATR  

Infection and immunity 20190919 10


<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins bindin  ...[more]

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