Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC6759387 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Shi Junfeng J Schneider Joel P JP
Angewandte Chemie (International ed. in English) 20190726 39
Selectively targeting the membrane-perturbing potential of peptides towards a distinct cellular phenotype allows one to target distinct populations of cells. We report the de novo design of a new class of peptide whose ability to perturb cellular membranes is coupled to an enzyme-mediated shift in the folding potential of the peptide into its bioactive conformation. Cells rich in negatively charged surface components that also highly express alkaline phosphatase, for example many cancers, are su ...[more]