Ontology highlight
ABSTRACT:
SUBMITTER: Eze FU
PROVIDER: S-EPMC6759663 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Eze Florence Uchenna FU Okoro Uchechukwu Christopher UC Ugwu David Izuchukwu DI Okafor Sunday N SN
Frontiers in chemistry 20190918
Bacterial resistance to antibiotics has become one of the most challenging problems of infectious disease treatment. Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their <i>in vivo</i> anti-inflammatory, <i>in vitro</i> anti-microbial and anti-oxidant activities. The base promoted reactions of the appropriate amino acids with substituted benzenesulphonyl chlorides gave the benzene sulphonamides (<b>3a-j</b>) in excellent yields. ...[more]