Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC6760124 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Sun Xiaotian X Angelastro James M JM Merino David D Zhou Qing Q Siegelin Markus D MD Greene Lloyd A LA
Cell death & disease 20190924 10
Survivin (BIRC5, product of the BIRC5 gene) is highly expressed in many tumor types and has been widely identified as a potential target for cancer therapy. However, effective anti-survivin drugs remain to be developed. Here we report that both vector-delivered and cell-penetrating dominant-negative (dn) forms of the transcription factor ATF5 that promote selective death of cancer cells in vitro and in vivo cause survivin depletion in tumor cell lines of varying origins. dn-ATF5 decreases levels ...[more]