Ontology highlight
ABSTRACT:
SUBMITTER: Xia F
PROVIDER: S-EPMC2519733 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Xia Fang F Canovas Pedro M PM Guadagno Thomas M TM Altieri Dario C DC
Molecular and cellular biology 20080630 17
Aberrant cell division is a hallmark of cancer, but the molecular circuitries of this process in tumor cells are not well understood. Here, we used a high-throughput proteomics screening to identify novel molecular partners of survivin, an essential regulator of mitosis overexpressed in cancer. We found that survivin associates with the small GTPase Ran in an evolutionarily conserved recognition in mammalian cells and Xenopus laevis extracts. This interaction is regulated during the cell cycle, ...[more]