Ontology highlight
ABSTRACT:
SUBMITTER: Kuchenbaecker K
PROVIDER: S-EPMC6760173 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190924 1
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23-0.28, p < 1.9 × 10<sup>-1 ...[more]