IgM in human immunity to Plasmodium falciparum malaria.
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ABSTRACT:
SUBMITTER: Boyle MJ
PROVIDER: S-EPMC6760923 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
IgM in human immunity to <i>Plasmodium falciparum</i> malaria.
Boyle M J MJ Chan J A JA Handayuni I I Reiling L L Feng G G Hilton A A Kurtovic L L Oyong D D Piera K A KA Barber B E BE William T T Eisen D P DP Minigo G G Langer C C Drew D R DR de Labastida Rivera F F Amante F H FH Williams T N TN Kinyanjui S S Marsh K K Doolan D L DL Engwerda C C Fowkes F J I FJI Grigg M J MJ Mueller I I McCarthy J S JS Anstey N M NM Beeson J G JG
Science advances 20190925 9
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in <i>Plasmodium falciparum</i> infection and is prominent during malaria in children and adults with lifetim ...[more]
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