Ontology highlight
ABSTRACT:
SUBMITTER: Khan S
PROVIDER: S-EPMC6761111 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190925 1
Innate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared to other tissues, but the mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques and mice, we show that low basal expression of RNA-sensing pattern recognition receptors (PRRs), or their co-receptors, in the LFRT contributes to high viral replication in this tissue. In the LFRT, ZIKV sensing provides limited ...[more]