Ontology highlight
ABSTRACT:
SUBMITTER: Yu T
PROVIDER: S-EPMC6761150 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yu Tao T Gan Shucheng S Zhu Qingchen Q Dai Dongfang D Li Ni N Wang Hui H Chen Xiaosong X Hou Dan D Wang Yan Y Pan Qiang Q Xu Jing J Zhang Xingli X Liu Junli J Pei Siyu S Peng Chao C Wu Ping P Romano Simona S Mao Chaoming C Huang Mingzhu M Zhu Xiaodong X Shen Kunwei K Qin Jun J Xiao Yichuan Y
Nature communications 20190925 1
Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 polarization. Mechanistically, Trim24, a CBP-associated E3 ligase, promotes Stat6 acetylation by catalyzing CBP ubiquitination at Lys119 to facilitate the recruitment of CBP to Stat6. Loss of Trim24 inhibits St ...[more]