Ontology highlight
ABSTRACT:
SUBMITTER: Patel PH
PROVIDER: S-EPMC6761285 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Patel Parthive H PH Pénalva Clothilde C Kardorff Michael M Roca Marianne M Pavlović Bojana B Thiel Anja A Teleman Aurelio A AA Edgar Bruce A BA
Nature communications 20190925 1
Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that sense epithelial damage remain poorly understood. Here we report that p38 signaling is activated in adult Drosophila midgut enterocytes in response to diverse stresses including pathogenic bacterial infection and chemical and mechanical insult. Two upstream kinases, Ask1 and Licorne (MKK3), are required for p38 activation following infecti ...[more]