Ontology highlight
ABSTRACT:
SUBMITTER: Sun M
PROVIDER: S-EPMC6762216 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
PLoS genetics 20190916 9
Gene expression is subject to stochastic noise, but to what extent and by which means such stochastic variations are coordinated among different genes are unclear. We hypothesize that neighboring genes on the same chromosome co-fluctuate in expression because of their common chromatin dynamics, and verify it at the genomic scale using allele-specific single-cell RNA-sequencing data of mouse cells. Unexpectedly, the co-fluctuation extends to genes that are over 60 million bases apart. We provide ...[more]