Ontology highlight
ABSTRACT:
SUBMITTER: Park SJ
PROVIDER: S-EPMC5775451 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Park Seong Jun SJ Song Sanggeun S Yang Gil-Suk GS Kim Philip M PM Yoon Sangwoon S Kim Ji-Hyun JH Sung Jaeyoung J
Nature communications 20180119 1
Gene expression is a complex stochastic process composed of numerous enzymatic reactions with rates coupled to hidden cell-state variables. Despite advances in single-cell technologies, the lack of a theory accurately describing the gene expression process has restricted a robust, quantitative understanding of gene expression variability among cells. Here we present the Chemical Fluctuation Theorem (CFT), providing an accurate relationship between the environment-coupled chemical dynamics of gen ...[more]