Ontology highlight
ABSTRACT:
SUBMITTER: Waltereit R
PROVIDER: S-EPMC6762636 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
Waltereit R R Dammermann B B Wulff P P Scafidi J J Staubli U U Kauselmann G G Bundman M M Kuhl D D
The Journal of neuroscience : the official journal of the Society for Neuroscience 20010801 15
Long-term potentiation (LTP) is a cellular model for persistent synaptic plasticity in the mammalian brain. Like several forms of memory, long-lasting LTP requires cAMP-mediated activation of protein kinase A (PKA) and is dependent on gene transcription. Consequently, activity-dependent genes such as c-fos that contain cAMP response elements (CREs) in their 5' regulatory region have been studied intensely. More recently, arg3.1/arc became of interest, because after synaptic stimulation, arg3.1/a ...[more]