Ontology highlight
ABSTRACT:
SUBMITTER: van den Ameele J
PROVIDER: S-EPMC6763261 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
van den Ameele Jelle J Brand Andrea H AH
eLife 20190912
Translating advances in cancer research to clinical applications requires better insight into the metabolism of normal cells and tumour cells in vivo. Much effort has focused on understanding how glycolysis and oxidative phosphorylation (OxPhos) support proliferation, while their impact on other aspects of development and tumourigenesis remain largely unexplored. We found that inhibition of OxPhos in neural stem cells (NSCs) or tumours in the <i>Drosophila</i> brain not only decreases proliferat ...[more]