Ontology highlight
ABSTRACT:
SUBMITTER: Hadzijusufovic E
PROVIDER: S-EPMC6763335 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Hadzijusufovic Emir E Peter Barbara B Rebuzzi Laura L Baumgartner Christian C Gleixner Karoline V KV Gruze Alexander A Thaiwong Tuddow T Pickl Winfried F WF Yuzbasiyan-Gurkan Vilma V Willmann Michael M Valent Peter P
Veterinary immunology and immunopathology 20090518 2-4
Systemic mastocytosis (SM) in felines is a rare neoplasm defined by increased growth and accumulation of immature mast cells (MC) in various organs including the spleen. Although in many cases splenectomy is an effective approach, relapses may occur. In these patients, treatment options are limited. Recent data suggest that various Kit tyrosine kinase inhibitors (TKI) interfere with growth of neoplastic MC in humans. In the current study, we examined the effects of four TKI, imatinib, midostauri ...[more]