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Vinyl Triflate-Aldehyde Reductive Coupling-Redox Isomerization Mediated by Formate: Rhodium-Catalyzed Ketone Synthesis in the Absence of Stoichiometric Metals.

ABSTRACT: Direct conversion of aldehydes to ketones is achieved via rhodium-catalyzed vinyl triflate-aldehyde reductive coupling-redox isomerization mediated by potassium formate. This method circumvents premetalated C-nucleophiles and discrete redox manipulations typically required to form ketones from aldehydes.

SUBMITTER: Shuler WG

PROVIDER: S-EPMC6763374 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Vinyl Triflate-Aldehyde Reductive Coupling-Redox Isomerization Mediated by Formate: Rhodium-Catalyzed Ketone Synthesis in the Absence of Stoichiometric Metals.

Shuler William G WG Swyka Robert A RA Schempp Tabitha T TT Spinello Brian J BJ Krische Michael J MJ

Chemistry (Weinheim an der Bergstrasse, Germany) 20190904 54

Direct conversion of aldehydes to ketones is achieved via rhodium-catalyzed vinyl triflate-aldehyde reductive coupling-redox isomerization mediated by potassium formate. This method circumvents premetalated C-nucleophiles and discrete redox manipulations typically required to form ketones from aldehydes. ...[more]

PMID: 31403727

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