Ontology highlight
ABSTRACT:
SUBMITTER: Swyka RA
PROVIDER: S-EPMC6376962 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190129 5
The first intermolecular carbonyl arylations via transfer hydrogenative reductive coupling are described. Using rhodium catalysts modified by <sup>t</sup>Bu<sub>2</sub>PMe, sodium formate-mediated reductive coupling of aryl iodides with aldehydes occurs in a chemoselective fashion in the presence of protic functional groups and lower halides. This work expands the emerging paradigm of transfer hydrogenative coupling as an alternative to pre-formed carbanions or metallic reductants in C═X additio ...[more]