Ontology highlight
ABSTRACT:
SUBMITTER: Shi G
PROVIDER: S-EPMC6763376 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Neuron 20190828 6
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater understanding of sleep regulation is necessary. We have identified a mutation in the β<sub>1</sub>-adrenergic receptor gene in humans who require fewer hours of sleep than most. In vitro, this mutation leads to decreased protein stability and dampened signaling in response to ago ...[more]