Ontology highlight
ABSTRACT:
SUBMITTER: Tedeschi A
PROVIDER: S-EPMC6763392 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tedeschi Andrea A Dupraz Sebastian S Curcio Michele M Laskowski Claudia J CJ Schaffran Barbara B Flynn Kevin C KC Santos Telma E TE Stern Sina S Hilton Brett J BJ Larson Molly J E MJE Gurniak Christine B CB Witke Walter W Bradke Frank F
Neuron 20190807 6
Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating the molecular mechanisms that drive morphogenetic transformation of neurons during development. Genetic loss- and gain-of-function experiments followed by time-lapse microscopy, in vivo imaging, and whole-mount analysis show that axon regeneration is fueled by elevated actin turnover. Act ...[more]