Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6763437 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhang Xiaolan X Lin Chun C Song Junwei J Chen Han H Chen Xuhong X Ren Liangliang L Zhou Zhongqiu Z Pan Jinyuan J Yang Zhenjun Z Bao Wenhao W Ke Xueping X Yang Jianan J Liang Yingying Y Huang Hongbiao H Tang Daolin D Jiang Lili L Liu Jinbao J
Cell death & disease 20190926 10
The ubiquitin-proteasome system (UPS) is a tight homeostatic control mechanism of intracellular protein degradation and turnover involved in many human diseases. Proteasome inhibitors were initially developed as anticancer agents with potential benefits in the suppression of tumor growth. However, clinical trials of patients with solid tumors fail to demonstrate the same efficacy of these proteasome inhibitors. Here, we show that Parkin, an E3 ubiquitin ligase, is implicated in tumorigenesis and ...[more]