Ontology highlight
ABSTRACT:
SUBMITTER: Ershaid N
PROVIDER: S-EPMC6763472 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ershaid Nour N Sharon Yoray Y Doron Hila H Raz Yael Y Shani Ophir O Cohen Noam N Monteran Lea L Leider-Trejo Leonor L Ben-Shmuel Amir A Yassin Muhammad M Gerlic Motti M Ben-Baruch Adit A Pasmanik-Chor Metsada M Apte Roni R Erez Neta N
Nature communications 20190926 1
Cancer-Associated Fibroblasts (CAFs) were shown to orchestrate tumour-promoting inflammation in multiple malignancies, including breast cancer. However, the molecular pathways that govern the inflammatory role of CAFs are poorly characterised. In this study we found that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β. This upregulation was evide ...[more]