A study of the properties of Gaussian mixture model for stable isotope standard quantification in MALDI-TOF MS.
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ABSTRACT:
SUBMITTER: Spainhour JCG
PROVIDER: S-EPMC6764515 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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A study of the properties of Gaussian mixture model for stable isotope standard quantification in MALDI-TOF MS.
Spainhour John Christian G JCG Janech Michael G MG Ramakrishnan Viswanathan V
Communications in statistics: Simulation and computation 20180130 6
The quantification of peptides in Matrix assisted laser desorption/ionization time-of-flight mass spectrum analysis coupled with stable isotope standards has been used to quantify native peptides under many experimental conditions. This approach has difficulties quantifying samples containing peptides with ion currents in overlapping (convolved) spectra. In a previous article we proposed a reparametrized Gaussian mixture model based on the known characteristics of the peptides that could also ac ...[more]
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