Ontology highlight
ABSTRACT:
SUBMITTER: Parker MW
PROVIDER: S-EPMC6764820 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
eLife 20190927
The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement of isolated origins functioning autonomously; the extent of inter-origin organization and communication is unknown. Here, we report that the replication initiation machinery of <i>D. melanogaster</i> ...[more]