Ontology highlight
ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC6764862 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Shi Hongxue H Hardesty Josiah E JE Jin Jian J Head Kimberly Z KZ Falkner K Cameron KC Cave Matthew C MC Prough Russell Allen RA
Xenobiotica; the fate of foreign compounds in biological systems 20190416 12
1. Aryl hydrocarbon receptor (AhR) ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs), are endocrine disrupting chemicals associated with nonalcoholic fatty liver disease. This study documents the species-specific differences between mouse (high affinity mAhR) and human AhR (hAhR) activation by PCB congeners and Aroclor mixtures. 2. AhR activation by TCDD or PCBs 77, 81, 114, 114, 126, and 169 was measured using luciferase reporter constructs trans ...[more]