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Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents.

ABSTRACT: A hybrid transition-metal/radical process is described that results in the addition of organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic fashion. The reaction can be accomplished both intermolecularly and intramolecularly, providing useful product yields and high enantioselectivities in both manifolds.

SUBMITTER: Chierchia M

PROVIDER: S-EPMC6764867 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents.

Chierchia Matteo M Xu Peilin P Lovinger Gabriel J GJ Morken James P JP

Angewandte Chemie (International ed. in English) 20190828 40

A hybrid transition-metal/radical process is described that results in the addition of organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic fashion. The reaction can be accomplished both intermolecularly and intramolecularly, providing useful product yields and high enantioselectivities in both manifolds. ...[more]

PMID: 31390474

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