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Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents.

ABSTRACT: The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloallylation in good to excellent yield. In a related copper-free transformation, allylic carbonates are found to engage in direct allylic substitution with diorganozinc reagents.

SUBMITTER: Komanduri V 

PROVIDER: S-EPMC2865154 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents.

Komanduri Venukrishnan V   Pedraza Fernando F   Krische Michael J MJ  

Advanced synthesis & catalysis 20080701 10

The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloallylation in good to excellent yield. In a related copper-free transformation, allylic carbonates are found to engage in direct allylic substitution with diorganozinc reagents. ...[more]

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