Ontology highlight
ABSTRACT:
SUBMITTER: Irony-Tur Sinai M
PROVIDER: S-EPMC6765107 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Irony-Tur Sinai Michal M Salamon Anita A Stanleigh Noemie N Goldberg Tchelet T Weiss Aryeh A Wang Yuh-Hwa YH Kerem Batsheva B
Nucleic acids research 20191001 18
Common fragile sites (CFSs) are genomic regions prone to breakage under replication stress conditions recurrently rearranged in cancer. Many CFSs are enriched with AT-dinucleotide rich sequences (AT-DRSs) which have the potential to form stable secondary structures upon unwinding the double helix during DNA replication. These stable structures can potentially perturb DNA replication progression, leading to genomic instability. Using site-specific targeting system, we show that targeted integrati ...[more]