Ontology highlight
ABSTRACT:
SUBMITTER: Bosco N
PROVIDER: S-EPMC3590843 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chromosoma 20120713 5
Mouse telomeres have been suggested to resemble common fragile sites (CFS), showing disrupted TTAGGG fluorescent in situ hybridization signals after aphidicolin treatment. This "fragile" telomere phenotype is induced by deletion of TRF1, a shelterin protein that binds telomeric DNA and promotes efficient replication of the telomeric ds[TTAGGG]n tracts. Here we show that the chromosome-internal TTAGGG repeats present at human chromosome 2q14 form an aphidicolin-induced CFS. TRF1 binds to and stab ...[more]