Ontology highlight
ABSTRACT:
SUBMITTER: Sanford TJ
PROVIDER: S-EPMC6765113 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nucleic acids research 20191001 18
Members of the Flaviviridae family, including dengue virus (DENV) and yellow fever virus, cause serious disease in humans, whilst maternal infection with Zika virus (ZIKV) can induce microcephaly in newborns. Following infection, flaviviral RNA genomes are translated to produce the viral replication machinery but must then serve as a template for the transcription of new genomes. However, the ribosome and viral polymerase proceed in opposite directions along the RNA, risking collisions and abort ...[more]