Ontology highlight
ABSTRACT:
SUBMITTER: Zahner C
PROVIDER: S-EPMC6766782 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Zahner Catherine C Kruttschnitt Esther E Uricher Julia J Lissy Michael M Hirsch Martin M Nicolussi Simon S Krähenbühl Stephan S Drewe Jürgen J
Clinical pharmacology and therapeutics 20190323 2
Hypericum perforatum L. (St. John's wort) is used to treat mild-to-moderate depression. Its potential safety risks are pharmacokinetic drug interactions via cytochrome P450 (CYP) enzymes and P-glycoprotein, presumably caused by hyperforin. In a phase I, open-label, nonrandomized, single-sequence study, the low-hyperforin Hypericum extract Ze 117 was investigated using a drug cocktail in 20 healthy volunteers. No pharmacokinetic interactions of Ze 117 were observed for CYP1A2, CYP2B6, CYP2C9, CYP ...[more]