Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.
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ABSTRACT:
SUBMITTER: Tahira AC
PROVIDER: S-EPMC6767407 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.
Tahira Ana Carolina AC Barbosa André Rocha AR Feltrin Arthur Sant'Anna AS Gastaldi Vinicius Daguano VD de Toledo Victor Hugo Calegari VHC de Carvalho Pereira José Geraldo JG Lisboa Bianca Cristina Garcia BCG de Souza Reis Viviane Neri VN Dos Santos Ana Cecília Feio ACF Maschietto Mariana M Brentani Helena H
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20181209 6
The male-biased prevalence of certain neurodevelopmental disorders and the sex-biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP-seq/chip data showed that SOX3/SRY gene targets were expressed ...[more]
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