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Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study.


ABSTRACT:

Aim

The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland.

Methods

This population-based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%.

Results

In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was -6% (95% CI -16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts.

Conclusion

Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative.

SUBMITTER: Eythorsson E 

PROVIDER: S-EPMC6767502 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study.

Eythorsson Elias E   Sigurdsson Samuel S   Erlendsdóttir Helga H   Hrafnkelsson Birgir B   Kristinsson Karl G KG   Haraldsson Ásgeir Á  

Acta paediatrica (Oslo, Norway : 1992) 20190217 8


<h4>Aim</h4>The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland.<h4>Methods</h4>This population-based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis m  ...[more]

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