Dataset Information

Changes in Biomarker Status in Metastatic Breast Cancer and Their Prognostic Value.

ABSTRACT:

Purpose

There is cumulative evidence that changes in biomarker status occur frequently during the metastatic progression of breast cancer and affect treatment response. The purpose of this study was to evaluate the frequency of biomarker changes in metastatic breast cancer (MBC) and its impact on prognosis.

Methods

A total of 152 patients diagnosed with MBC at the time of initial diagnosis or during post-surgical follow-up were included. Changes in biomarker status in MBCs, their frequency according to various metastatic sites, tumor characteristics, and their association with patient survival were analyzed.

Results

Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 status changed in 9 (6.0%), 40 (26.3%), 12 (7.9%), and 29 (19.1%) patients, respectively. ER, PR, and HER2 mainly showed positive to negative conversion, whereas Ki-67 changed mostly from a low to high index. There were no differences in the frequencies of biomarker changes according to the metastatic sites. As for ER and HER2, cases with negative conversion showed low expression levels in the primary tumor. Survival analyses indicated that a positive to negative conversion of ER was an independent poor prognostic factor in patients with primary ER-positive breast cancer.

Conclusion

Changes in biomarker status are not rare, and usually occur in an unfavorable direction in breast cancer metastases. Negative conversion of ER status is a predictor of poor prognosis. Thus, it is beneficial to evaluate changes in biomarker status in MBC not only for the purpose of determining treatment options but also for prognostication of patients.

SUBMITTER: Woo JW

PROVIDER: S-EPMC6769393 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Changes in Biomarker Status in Metastatic Breast Cancer and Their Prognostic Value.

Woo Ji Won JW Chung Yul Ri YR Ahn Soomin S Kang Eunyoung E Kim Eun-Kyu EK Kim Se Hyun SH Kim Jee Hyun JH Kim In Ah IA Park So Yeon SY

Journal of breast cancer 20190901 3

<h4>Purpose</h4>There is cumulative evidence that changes in biomarker status occur frequently during the metastatic progression of breast cancer and affect treatment response. The purpose of this study was to evaluate the frequency of biomarker changes in metastatic breast cancer (MBC) and its impact on prognosis.<h4>Methods</h4>A total of 152 patients diagnosed with MBC at the time of initial diagnosis or during post-surgical follow-up were included. Changes in biomarker status in MBCs, their ...[more]

PMID: 31598343

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Dataset Information

Changes in Biomarker Status in Metastatic Breast Cancer and Their Prognostic Value.

Purpose

Methods

Results

Conclusion

Publications

Changes in Biomarker Status in Metastatic Breast Cancer and Their Prognostic Value.

Similar Datasets

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