Ontology highlight
ABSTRACT:
SUBMITTER: Leung CH
PROVIDER: S-EPMC6770765 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Leung Chung-Hang CH Zhang Jia-Tong JT Yang Guan-Jun GJ Liu Hao H Han Quan-Bin QB Ma Dik-Lung DL
International journal of molecular sciences 20190910 18
Due to role of the Keap1-Nrf2 protein-protein interaction (PPI) in protecting cells from oxidative stress, the development of small molecule inhibitors that inhibit this interaction has arisen as a viable approach to combat maladies caused by oxidative stress, such as cancers, neurodegenerative disease and diabetes. To obtain specific and genuine Keap1-Nrf2 inhibitors, many efforts have been made towards developing new screening approaches. However, there is no inhibitor for this target entering ...[more]